Transient neonatal diabetes mellitus
Transient neonatal diabetes mellitus (TNDB) is a type of diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood.[1] Affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy.[2] Approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24.[3][4] These cases are referred to as 6q24-related TNDB; most (but not all) of these cases are not inherited.[4] Other genetic causes include mutations in the KCNJ11 and ABCC8 genes, which usually cause permanent neonatal diabetes.[3] Treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin.
Original Article Source Credits: Genetic and Rare Diseases Information Center ,https://rarediseases.info.nih.gov/
Article Written By: NA
Original Article Posted on: NA
Link to Original Article: https://rarediseases.info.nih.gov/diseases/1839/transient-neonatal-diabetes-mellitus